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# Neutrophil-chemoattractant CXCL5 increases lung barrier permeability in acute lung injury
- URL: https://www.alveotalks.com/neutrophil-chemoattractant-cxcl5-increases-lung-barrier-permeability-in-acute-lung-injury/
- Published: 2025-12-29T17:15:00.000Z
- Updated: 2026-02-22T14:29:57.000Z
- Author: Elena Lopez-Rodriguez
- Tags: The alveolar epithelial glycocalyx, #Open Access, #Publication

Berger, S., Goekeri, C., Pennitz, P., Gutbier, B., Michalick, L., Hoffmann, K., **Lopez-Rodriguez**, E., Gluhovic, V., Wienhold, S.M., Behrendt, U., Taylor, A., Dietert, K., Kirsten, H., Kunder, S., Mueller, K., Weigel, M., Hain, T., Volkers, S.M., Weis, S., Gruber, A.D., Sander, L.E., Kuebler, W.M., CAPSyS study group, Witzenrath, M., Nouailles, G. Mucosal Immunology, Volume 18, Issue 6, 1438 - 1449

To access the full article, [click here](https://www.mucosalimmunology.org/article/S1933-0219%2825%2900105-9/fulltext?ref=alveotalks.com): 

[![](https://www.alveotalks.com/content/images/2024/03/open-access.png)](https://www.mucosalimmunology.org/article/S1933-0219%2825%2900105-9/fulltext?ref=alveotalks.com)

Acute lung injury is a common complication of pneumonia, with disease severity linked to inflammatory cell recruitment and lung barrier dysfunction. In this study, we investigate the role of neutrophil-chemoattractant CXCL5 in lung barrier function and inflammation.We examined CXCL5 in patients with severe pneumonia and in *in vitro* and *in vivo* models of acute lung injury. Pneumococcal infection and mechanical ventilation triggered CXCL5 release in both humans and mice. In *Cxcl5*\-deficient mice, the alveolar-epithelial barrier remained intact despite acute lung injury, independent of alveolar neutrophil recruitment. Single-cell transcriptomics revealed enhanced cell junctional transcripts in epithelial cells of *Cxcl5*\-deficient mice. Consistently, CXCL5 exposure disrupted the barrier function of TNF-primed human primary alveolar epithelial cells.Beyond its known role in neutrophil recruitment, CXCL5 independently increases alveolar-epithelial barrier permeability. Therefore, targeting CXCL5 inhibition as adjunctive therapy with antibiotics in severe bacterial pneumonia may help reduce excessive inflammation and preserve lung barrier function.