Open Access

46 posts

We believe in the importance of sharing the new knowledge that research creates along our work. Therefore we promote the access of everyone to our publications by making them open access. Here you can find the complete list of our open access publications

Mechanical strain exacerbates Pseudomonas infection in an organoid-based pneumonia-on-a-chip model

Copyright: © 2025 The Author(s). Published by Elsevier Inc. on behalf of Society for Mucosal Immunology. Karen Hoffmann, Ulrike Behrendt, Peter Pennitz, Holger Kirsten, Jessica Pohl, Elena Lopez-Rodriguez, Chantal Weissfuss, Jens Kollmeier, Mario Tönnies, Sebastian Brill, Konrad Steinestel, Martin Witzenrath, Werner Wenzel, Christian Zobel, and Geraldine Nouailles. J Clin Invest.

1 min read

Neutrophil-chemoattractant CXCL5 increases lung barrier permeability in acute lung injury

Sarah Berger, Cengiz Goekeri, Peter Pennitz, Birgitt Gutbier, Laura Michalick, Karen Hoffmann, Elena Lopez-Rodriguez, Vladimir Gluhovic, Sandra-Maria Wienhold, Ulrike Behrendt, Alexander Taylor, Kristina Dietert, Holger Kirsten, Sandra Kunder, Kristina Mueller, Markus Weigel, Torsten Hain, Sarah M. Volkers, Sebastian Weis, Achim D. Gruber, Leif E. Sander, Wolfgang M. Kuebler, CAPSyS study

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Cholesterol-mediated inflammation activation in alveolar macrophages

Registered Report

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Enzymatic modulation of the pulmonary glycocalyx enhances susceptibility to Streptococcus pneumoniae

Cengiz Goekeri, Kerstin A.K. Linke, Karen Hoffmann, Elena Lopez-Rodriguez, Vladimir Gluhovic, Anne Voß, Sandra Kunder, Andreas Zappe, Sara Timm, Alina Nettesheim, Sebastian M.K. Schickinger, Christian M. Zobel, Kevin Pagel, Achim D Gruber, Matthias Ochs, Martin Witzenrath, Geraldine Nouailles. Am J Res Cell Mol Biol 2024: 71(6):646-658.

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Comparative electron microscopic visualization of the lung alveolar epithelial glycocalyx with different staining and labeling methods

Vladimir Gluhovic, Sara Timm, Wolfgang M. Kuebler, Elena Lopez-Rodriguez, Matthias Ochs. Journal of Anatomy 2025;246(5):770-81. To access the full article, click here: The alveolar surface of the lung is lined by an epithelium consisting of type I (AECI) and type II alveolar epithelial cells (AECII). This epithelium

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Multivalent, calcium-independent binding of surfactant protein A and D to sulfated glycosaminoglycans of the alveolar epithelial glycocalyx

SP-A and SP-D function has been related to innate immunity of the lung based on their binding to sugar residues at pathogen surfaces. Here, we demonstrated that these proteins bind to glycosaminoglycans present at typical cell surfaces like the alveolar epithelial glycocalyx.

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The unremarkable alveolar epithelial glycocalyx: a thorium dioxide-based electron microscopic comparison after heparinase or pneumolysin treatment

The present study provides quantitative data on the differential glycocalyx distribution on AEI and AEII based on cThO2 and demonstrates alveolar glycocalyx shedding in response to HEP or PLY resulting in a structural reduction in both glycosaminoglycan height and density.

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Ten simple rules for implementing open and reproducible research practices after attending a training course

We describe ten simple rules to guide participants of relevant training courses in implementing robust research practices in their own projects, once they return to their research group.

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Resting time after phorbol 12-myristate 13-acetate in THP-1 derived macrophages provides a non-biased model for the study of NLRP3 inflammasome

Differentiation of THP-1 with 5ng/ml PMA followed by 24h resting period provides a model that morphologically and molecularly resembles macrophages.

2 min read

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