The alveolar epithelial glycocalyx

11 posts

In this project we aim to investigate the sugar-coating of the alveolar epithelial cells. This quite unknown glycocalyx of the lung may have a greater impact in the lung disease than expected, being at the border between the air and our lung tissue. At this very special location, we hypothesise that the glycocalyx may interact and play a key role on lung surfactant arrangement and function.

Metabolic Glycoengineering Enables the Ultrastructural Visualization of Sialic Acids in the Glycocalyx of the Alveolar Epithelial Cell Line hAELVi

Brandt, R., Timm, S., Gorenflos López, J.L., Kwame Abledu, J., Kuebler, W.M., Hackenberger, C.P.R., Ochs, M., Lopez-Rodriguez, E.: Front Bioeng Biotech. 2021;8:614357. To access the full article, click here: The glycocalyx—a plethora of sugars forming a dense layer that covers the cell membrane—

2 min read

On Top of the Alveolar Epithelium: Surfactant and the Glycocalyx

Ochs, M., Hegermann, J., Lopez-Rodriguez, E., Timm, S., Nouailles, G., Matuszak, J., Simmons, S., Witzenrath, M., Kuebler, W.M.: Int J Mol Sci. 2020;21(9). To access the full article, click here: Gas exchange in the lung takes place via the air-blood barrier in the septal walls of alveoli.

1 min read

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