Raw data
Here you can find the raw data of our work:
* Cholesterol-mediated inflammation activation in alveolar macrophages https://zenodo.org/records/17367433
GitHub repository
In our GitHub repository you can find the R code used to analyse our data.
Single cell sequencing data in "Altered cholesterol immunometabolism activates the macrophage NLRP3-inflammasome in lung fibrosis" was analyzed with the code found here: https://github.com/Lopez-Giambelluca/LungChol
Multivalent, calcium-independent binding of surfactant protein A and D to sulfated glycosaminoglycans of the alveolar epithelial glycocalyx
Avcibas R., Vermul A., Gluhovic V., Boback N., Arroyo R., Kingma P.S., Isasi-Campillo M., Garcia-Ortega L., Griese M., Kuebler W.M., Ochs M., Lauster D., and Lopez-Rodriguez E. Am J Physiol-Lung Cell Mol Physiol 2024 326:5, L524-L538
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Lung surfactant collectins, surfactant
Characterization of commercially available human primary alveolar epithelial cells
Herbst, C.J., Lopez-Rodriguez, E., Gluhovic, V., Schulz, S., Brandt, R., Timm, S., Abledu, J., Falivene, J., Pennitz, P., Kirsten, K., Nouailles, G., Witzenrath, M., Ochs, M., and Kuebler, W.M. Am J Respir Cell Mol Biol., 2024, 70 (5), 339-350
In vitro lung research requires appropriate cell culture models
The unremarkable alveolar epithelial glycocalyx: a thorium dioxide-based electron microscopic comparison after heparinase or pneumolysin treatment
Timm, S., Lettau, M., Hegermann, J., Rocha, M.L., Weidenfeld, S., Fatykhova, D., Gutbier, B., Nouailles, G., Lopez-Rodriguez, E., Hocke, A., Hippenstiel, S., Witzenrath, M., Kuebler, W.M., Ochs, M.: Histochem Cell Biol. 2023;160(2):83-96.
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Recent investigations analyzed in depth the
Ten simple rules for implementing open and reproducible research practices after attending a training course
Heise, V., Holman, C., Lo, H., Lyras, E.M., Adkins, M.C., Aquino, M.R.J., Bougioukas, K.I., Bray, K.O., Gajos, M., Guo, X., Hartling, C., Huerta-Gutierrez, R., Jindrová, M., Kenney, J.P.M., Kępińska, A.P., Kneller, L., Lopez-Rodriguez, E.,... Weissberger T.C.,: PLoS Comput Biol. 2023;
Resting time after phorbol 12-myristate 13-acetate in THP-1 derived macrophages provides a non-biased model for the study of NLRP3 inflammasome
Giambelluca, S., Ochs, M., Lopez-Rodriguez, E.: Front Immunol. 2022;13:958098.
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Background: The activation of NLRP3 inflammasome in macrophages has been proven to play a crucial role in the development of cardiovascular diseases. THP-1 monocytes can be differentiated to macrophages by incubation with
Human alveolar progenitors generate dual lineage bronchioalveolar organoids
Hoffmann, K., Obermayer, B., Hönzke, K., Fatykhova, D., Demir, Z., Löwa, A., Alves, L.G.T., Wyler, E., Lopez-Rodriguez, E., Mieth, M., Baumgardt, M., Hoppe, J., Firsching, T.C., Tönnies, M., Bauer, T.T., Eggeling, S., Tran, H.L., Schneider, P., Neudecker, J., Rückert, J.C., Gruber, A.D., Ochs,
The ultrastructural heterogeneity of lung surfactant revealed by serial section electron tomography: insights into the 3-D architecture of human tubular myelin
Lettau, M., Timm, S., Dittmayer, C., Lopez-Rodriguez, E., Ochs, M.: Am J Physiol-Lung C. 2022;322(6):L873-81.
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Weibel’s hypothetical three-dimensional (3-D) model in 1966 provided first ultrastructural details into tubular myelin (TM), a unique, complex surfactant subtype found in the hypophase
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